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The price of many antidotes substantially increased in the United States from 2010 to 2015. This may impede timely treatment of patients, and negatively impact poisoning outcomes. The price increase over the last 5 years may further hinder the willingness of hospitals to stock recommended antidotes at adequate quantities. The high cost of antidotes has previously been cited as a factor leading to inadequate antidote supply at some hospitals. Only four antidotes demonstrated decreases in AWP greater than 10% and only one antidote had its cost of stocking decrease in AWP by more than $1000. Of the antidotes evaluated, 15 out of 33 had greater than 50% increase in AWP and 8 out of 33 had greater than $1000 increase in AWP. The cost of stocking many antidotes demonstrated a large increase in AWP from 2010 to 2015. The cost of minimum stocking levels for each antidote was calculated and compared between the year 20. Consumer Price Index to adjust for inflation.

The AWP in 2010 was adjusted using the U.S. average wholesale price (AWP) of each antidote in 20. RED BOOK Online ® was used to identify the U.S. This research aims to quantify recent trends in the costs of antidotes in the U.S.Īntidotes and minimum stocking recommendations were retrieved from published guidelines. Continued increases in the cost of antidotes may lead to further reductions in antidote supply and represent serious concerns. The high cost of antidotes has previously been cited as a factor leading to inadequate antidote supply at some hospitals. Our poison control center observed a large increase in the cost of many antidotes over the past several years.